OMFG LIFE IS WORTH LIVING NOW.
Such a profound topic to focus on. Islam’s views on “The Weakest of Homes”.
We were star-crossed lovers, our destiny engraved into the faraway entities. like the stars, we were meant to be, we were meant to be apart.
We were fingers-crossed lovers, holding onto pretense and sweaty fingers, lying shamelessly and loving even more unabashed.
We were legs-crossed lovers, sitting stagnant in a pool of dark waters. unmoving, because we knew any action will take us further away from the stars above us, from the stars between us.
We were eyes-crossed lovers, trying to force ourselves into looking in the same direction, though we couldn’t, though our views were never aligned.
We were lines-crossed lovers, doing the wrong things, at the wrong times. we crossed the final line one night, when we looked into each other’s crossed eyes, with our fingers crossed behind our backs, and claimed loves of a billion kinds.
we were lovers.
Most human tumors (about 90%) are of epithelial origin. Cancers that are derived from epithelial cells are carcinomas. Epithelial cells are found in many tissues and organs and they are a sheet-like lining that can serve a number of functions including secretion, protection, absorption and permeability.
Epithelial cells sit on top of a structure called the basement membrane or basal lamina. Under the basement membrane/basal lamina is the mass of tissue called the stroma. The basal lamina is part of the ECM. The stroma or mesenchyme (connective tissue) provides strength through fibrous proteins called collagens. The cells that produce collagen and are found in the stroma/connective tissue are fibroblasts.
Epithelial cells are in very close contact with each other. The space between them contains several junctions, including tight junctions that seal the space between the cells to prevent leakage. In addition, adherens junctions and desmosomes also bind epithelial cells to one another. Both adherens junctions and desmosomes require transmembrane proteins called cadherins. At adherens junctions the cadherins are attached to actin microfilaments of the cytoskeleton. While at the desmosomes, cadherins connect to intermediate filaments such as keratins.
Epithelial cells are also attached to the basal lamina (ECM layer) by transmembrane proteins that are attached to the cytoskeleton called integrins.
This is very important in understanding what makes cancer cells invasive and metastatic. Epithelial cells are normally locked into place, sitting on top of the basement membrane and attached to each other by tight junctions, adherens junctions and desmosomes. In order to line the cavity effectively and function they need to be locked into place. For cells to become invasive and metastatic, these anchors have to become dysfunctional.
There are four major types of new tissue growth – Hypertrophy, Hyperplasia, Dysplasia and Neoplasia.
Hypertrophy – An increase in cell size, normal organization
Hyperplasia – An increase in cell number, normal organization. Epithelium invades lumen, but not basement membrane or stroma. Cells appear normal in terms of organization, but they are growing when they shouldn’t be growing. Thus they are deregulated in terms of proliferation.
Dysplasia – Disorganized growth. Transition between benign and malignant. In addition to there being too many cells, they are disorganized and they don’t look like normal epithelial cells – they are piling up.
Neoplasia – Disorganized growth, net increase in the number of dividing cells. The cells are incredibly disorganized and they have broken through the basal lamina and invaded the stroma. These cells are invasive/malignant.
A growth that has stayed within the epithelial compartment is not technically considered cancer, it’s considered to be a benign growth. It becomes cancer/malignant/invasive/neoplastic only when it has broken out of the epithelial zone and invaded the underlying stroma.
I love how behind every single window, there is a different person who has a story that we know nothing about and I sometimes forget that my life isn’t the only life in the world. How much am I doing for others?
Consistency is an underrated human quality. Consistency fosters trust and promotes a desire to do and be better.
Do what you say you will do."
ED doctors must think fast and be able to make decisions quickly, but they also must be calm under pressure. When it’s crunch time, ED doctors must tune out all the distractions and noise around them. They must zero in on a problem and make quick, aggressive decisions.
A big part of what makes emergency medicine unique and compelling is the variety of patients and problems ED doctors care for. That’s another part of emergency medicine that appealed to me. You might see a person with terrible abdominal pain — then someone who suddenly can’t move his right arm and leg — and then a person who is seeing and talking to people who aren’t there. And all that is interspersed with people with bad colds, or twisted ankles, to give you a little breather.
You have to know just what to do, and fast, to handle a remarkably wide range of problems. Make the right decision, and you save a life. Make the wrong one, and the patient may get even sicker. And sometimes, you have just minutes to make your decision — or nature will make it for you.
Emergency medicine is the purest form of rapid diagnosis. Emergency doctors don’t get a patient with a diagnosis; instead, they get a patient with symptoms. It’s up to the doctor to make the right call.
ED doctors must be fast-paced, but able to stop on a dime; able to grasp the big picture, but detail-oriented; well-trained but flexible; able to make a decision, and often to lead a team of health professionals to provide urgent care for a patient.
If this sounds like the skill set required of a commander in battle, that’s because it is. And if it also sounds like the role of a point guard on an NBA basketball team, that’s because it is.
Dr. Anthony Komaroff | Harvard Medical School | “Ask Doctor K”
From Amy Purdy’s TEDxOrangeCoast talk, "Living beyond limits.” Amy is a professional snowboarder who lost her legs at age 19 due to bacterial meningitis. In her TEDx talk, she describes how she dealt with this loss, and encourages us to take control of our lives — and our limits.
Watch Amy’s entire talk below, and learn more about Amy and her non-profit Adaptive Action Sports, dedicated to introducing people with physical challenges to action sports at her website.